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The STEP trials behind Wegovy demonstrated up to 15% weight loss with semaglutide
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Thyroid C-cell tumours: Rodent studies with GLP-1 receptor agonists have shown C-cell tumours at clinically irrelevant exposures
GLP-1 and GIP/GLP-1 medications have boxed warnings regarding thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) and carry risks of pancreatitis, gallbladder disease, and diabetic retinopathy progression
Some people on standard maintenance notice tiredness, brain fog or tingling creeping back well before the next injection is due
The oral tirzepatide complete guide explores oral GLP-1 formulations
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